Nonequilibrium-Facilitated Oxygen Transport in Hemoglobin Solution
نویسندگان
چکیده
منابع مشابه
Steady-State, Hemoglobin-Facilitated O2 Transport in Human Erythrocytes
We measured the rate of oxygen transport through thin (165 micro) films of packed erythrocytes (Hb concentration = 30 g/100 ml). Under optimal conditions steady-state O(2) diffusion was nearly three times that found when the hemoglobin was prevented from acting as a carrier molecule by carbon monoxide binding or high oxygen back pressure. After each experiment we measured hemolysis and found th...
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The equations of facilitated diffusion were solved numerically for steady state diffusion of oxygen across membranes of hemoglobin and myoglobin. An interfacial resistance was included in the boundary conditions and the dependence of the solutions on membrane thickness and interfacial conductance was studied. The data of Wittenberg on millipore membranes was fitted adequately if a tortuosity fa...
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Hemoglobin in solution augments the rate of steady state diffusion of oxygen. The flux of oxygen exceeds the diffusive flux by an amount, the facilitated flux, which is constant for a given hemoglobin concentration and is invariant with changing oxygen tension. The facilitated flux is inversely proportional to the length of the diffusion path. Facilitation decreases with increasing molecular si...
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The dissociation of the horse hemoglobin molecule into 2 half molecules in 4 M urea solutions has been well established (16). The effect of concentrated urea on the equilibrium between oxygen and hemoglobin has, however, not been determined. The present experiments const.itute a study of this equilibrium. The reaction between oxygen and hemoglobin is best described if it is assumed that 4 molec...
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To study the effect of genetic differences in the maternal oxyhemoglobin dissociation curve on fetal O2 supply, we compared eight pregnant ewes homozygous for high O2 affinity hemoglobin (A) with eight pregnant ewes homozygous for low O2 affinity hemoglobin (B). Each ewe carried a single fetus. Fetal weights were not significantly different (A, 3,000 +/- 170 g; B, 3,070 +/- 270 g). The A ewes h...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1970
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(70)86284-1